Features such as edema and blood pressure elevation above the patient’s baseline no longer are diagnostic criteria.45 Severe preeclampsia is indicated by more substantial blood pressure elevations and a greater degree of proteinuria.
Recent research has indicated that the poor development of placenta may be responsible, preventing the transfer of nutrients from mother to baby that are essential to its healthy development.
Through our research we aim to find out specifically what it is that causes preeclampsia and to identify methods for earlier diagnosis of the condition, allowing us to manage it more effectively.
TY - THEST1 - Identification of Pre-eclampsia susceptibility genes AU - Gokhale-Agashe, Dnyanada Shrirang PY - 2018Y1 - 2018N2 - This thesis aimed to identify susceptibility genes contributing to Preeclampsia, a pregnancy specific disorder.
AB - This thesis aimed to identify susceptibility genes contributing to Preeclampsia, a pregnancy specific disorder.
By conservative estimates, these disorders are responsible for 76,000 maternal and 500,000 infant deaths each year.”“Every year in the UK about 1000 babies die because of pre-eclampsia – many of these as a consequence of premature delivery rather than the disease itself.
Some 7 mothers die each year from complications of pre-eclampsia in the UK.” Preeclampsia is characterized by high blood pressure (hypertension), fluid retention (oedema) and excessive protein levels in the urine (proteinuria).
Management during delivery includes seizure prophylaxis with magnesium sulfate and, if necessary, medical management of hypertension. Access to prenatal care, early detection of the disorder, careful monitoring, and appropriate management are crucial elements in the prevention of preeclampsia-related deaths.
Preeclampsia is a pregnancy-specific, multisystem disorder that is characterized by the development of hypertension and proteinuria after 20 weeks of gestation.
These symptoms are not evident during the early stages of pregnancy and as such preeclampsia can be difficult to diagnose.
It is only detectable by regular antenatal checks on maternal blood pressure and urine, and as such women without access to adequate healthcare services are particularly at risk. In severe cases the only way to relieve the mother’s symptoms is to artificially induce delivery or to prematurely deliver the child by emergency caesarian section.